Biology 435 - Cell Biology

Course Materials

Tools of the Trade

Other Good Links

  Syllabus

Access to GenBank and Medline at the  The National Center for Biotechnology Information (NCBI)

 HMS Beagle  - 
The BioMedNet Magazine

Lab Schedule

Molecular Visualization with
 RasMol and Chime

 American Society for Cell Biology

Integrated Informatics Project

  The RCSB Protein Data Bank

  American Society for Biochemistry and Molecular Biology

 

  Science Magazine 

 ExPASy - Swiss-Quiz 
Win Swiss Chocolate - really!!!

  Lecture Topics (Chapters)
PowerPoint Presentations (on campus only) 		Links for This Week's Discussion Topics
Week 1
Aug 30-Sep 3 		Biochemistry Review (Ch 2  pp. 41-60)
Nucleic Acid Review (Ch 3 89-110)
Lab: Bioinformatics with LaserGene 		 B-DNA Structure
Week 2
Sep 6-10 		Protein Structure (Ch 3 pp 89-96; 111-135)
Protein Function (5)
Lab: RasMol Tutorial 		 Protein Secondary Structure
 Protein G Structure Tutorial
Week 3
Sep 13-17 		Evolution of the Cell (Ch. 1 - all)
Lab: Chime Tutorials, 
Begin Integrated Informatics Projects 		 The G Protein Nanomachine
Week 4
Sep 20-24 		The Cytoskeleton -Microtubules (16)
Borisy Lab Group
Kinesin HomePage
Klymkowsky Lab
TGIF Journal Article:
Week 5
Sep 27-Oct 1 		The Cytoskeleton -Microfilaments (16)
Lab: Chick Primary Cell Cultures 		 TGIF Journal Articles:
Week 6
Oct 4-8 		 Membrane Structure/ Function (10)
Lab: Mouse Primary Cell Cultures		  TGIF Journal Article:
Week 7
Oct 11-15 		 Membrane Transport (11)
Lab: Isolation of RBC Ghosts, Extraction of membrane lipids.		 Potassium Channel Tutorial
TGIF Journal Articles: 
  • Philipson and Steiner (1995) Science 268:372-373 Pas de Deux or more: The sulfonylurea receptor and K+ channels.
  • Aguilar-Bryan et al (1995) Science 268:423-426 Cloning the ß cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
  • Thomas et al (1995) Science 268:426-429 Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy.
Week 8
Oct 18-22 		Protein Targeting (12)
Lab: Analysis of membrane lipids, SDS PAGE of proteins		  MITOMAP A human mitochondrial genome database
TGIF Journal Article: Long weekend, no article 
Week 9
Oct 25-29 		 Secretory/Endocytic Pathways (13)
Lab: Analysis of a cell surface receptor		  
Week 10
Nov 1-5 		Secretory/Endocytic Pathways (13),
Signal Transduction (15)
Lab: Integrated Informatics Project		  Journal Articles: 
Week 11
Nov 8-12  		 Signal Transduction (15)
Lab: Immunofluorescent Staining of Microtubules		 TGIF Journal Articles: 
Week 12
Nov 15-19  		The Cell Cycle/Mitosis (17,18)
Lab: Cellular response to growth factors - SDS-PAGE, Silver Stain, Transfer to membrane.		  
Week 13
Nov 29-Dec 3 		The Cell Cycle/Mitosis (17,18)

Lab: Cellular response to growth factors - Immunodetection of phosphorylated proteins.

 CNN - Sun-damaged cells may hold key to fighting skin cancer - August 5 1999
TGIF Journal Article: Hill et al., 1999, Science 285:898 - Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology
do Carmo Avides and Glover, 1999, Science 283:1733 - Abnormal Spindle Protein, Asp, and the Integrity of Mitotic Centrosomal Microtubule Organizing Centers.
Welcome to the Salmon Lab
Week 14
Dec 6-10 		 The Extracellular Matrix (19)
Lab: Present Integrated Informatics Projects		  TGIF Journal Articles: Giancotti and Ruoslahti (1999) Science 285:1028 Integrin Signaling

 Thomson et al. (1998) Embryonic Stem Cell Lines Derived from Human Blastocysts Science 282:1145. (also read the "related articles in Science" at the bottom)

This page was created or last modified on 8/30/99 by Jeff Newman
and has been accessed  times since 8/1/99.

Assistant Professor Web page: http://lyco.lycoming.edu/~newman
Department of Biology Email: newman@lycoming.edu
Lycoming College Phone: 570-321-4386
Williamsport PA 17701 Fax: 570-321-4073

© 1998, 1999  Jeffrey D. Newman